Both Wegovy and Zepbound are prescription medications designed to aid in weight loss, but they work slightly differently and suit different people. This guide breaks down the key differences, benefits, and considerations to help you understand which one might be the right fit.
How These Medications Work
Both Wegovy and Zepbound mimic hormones your body naturally produces to regulate appetite and fullness. However, Zepbound activates two hormone receptors (GLP-1 and GIP), while Wegovy only activates one (GLP-1). This dual action may explain why Zepbound tends to deliver more significant weight loss.
Who Can Use These Medications?
- Wegovy: Approved for adults and children (age 12+) with obesity (BMI of 30 or higher) or overweight (BMI of 27 or higher) with related health conditions. It also reduces heart risks in overweight individuals with existing heart disease.
- Zepbound: Currently approved only for adults with obesity or overweight with related health conditions. It also treats obstructive sleep apnea in obese adults.
Weight Loss Results: Which One Works Better?
Clinical trials show Zepbound leads to greater weight loss than Wegovy. Participants on the highest dose of Zepbound lost an average of 20% of their body weight over 72 weeks, while Wegovy resulted in 14% weight loss.
Dosage and Side Effects
- Wegovy: Starts at a low dose (0.25 mg) and gradually increases to a maximum of 2.4 mg.
- Zepbound: Increases more quickly, starting at 2.5 mg and potentially reaching 15 mg.
Both medications cause similar side effects: nausea, vomiting, diarrhea, and constipation. These usually improve as your body adjusts. Serious side effects are rare but can include pancreatitis, gallbladder problems, and mood changes.
Cost and Coverage
Both medications are expensive, with list prices exceeding $1,000 per month. Insurance coverage varies widely, and direct-to-consumer programs offer discounts (around $350-$500 per month).
Which One Should You Choose?
- For significant weight loss: Zepbound may be more effective.
- For heart health: Wegovy offers proven cardiovascular benefits.
- For sleep apnea: Zepbound is approved to treat this condition.
- If you’re under 18: Wegovy is currently the only approved option.
The Bottom Line
Wegovy and Zepbound are powerful tools for weight loss, but they aren’t magic bullets. Sustainable results require lifestyle changes, including healthy eating, regular exercise, and ongoing support from your healthcare provider.
Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication
